Prof. Dr. med. Jan M. Langrehr

Head of Department: Prof. Dr. med. Jan M. Langrehr
Certified Specialist in Surgery and Visceral Surgery                 
Specialisms: oncological surgery (tumour surgery), minimally invasive surgery

  • Higher Education, Training and Qualifications
    • 14.02.1963
      Second child of Barbara and Prof. Dr. D. Langrehr
      Civil status: married to Angela Langrehr
      Children Julius (13) and Rebecca (11)
    • September 1969
      Primary school
    • December 1980
      Pre-university qualification (Abitur) at Altes Gymnasium grammar school in Bremen
    • February 1981
      Military service with German army
    • April 1982
      Medical degree at Free University, Berlin
    • June 1988   
      State examinations and medical licence
  • Career
    • 8-88 to 1-89
      Assistant, surgical practice specialising in coloproctology, Dr. J. Kaese, Munich
    • 2-1989
      Research assistant at Clinic for General, Visceral and Transplant Surgery, Westend Clinic of the Free University of Berlin (Prof. Dr. P. Neuhaus)
    • 3-1989 to 9-1991
      Research fellow, Department of Surgery, University of Pittsburgh (Prof. Dr. R.L. Simmons)
    • 4-1989
      Doctorate awarded by Free University, Berlin
    • 10-1991
      Research assistant at Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus (Prof. Dr. P. Neuhaus)
    • 4-1992 to 7-1994
      Member of the research commission of the Charité / Virchow-Klinikum campus and responsible for planning and development of surgical research area and animal experimentation facilities at the newly built Biomed Research Centre on the Virchow-Klinikum campus
    • 11-1993 to 10-1994
      Research assistant at Clinic for Accident and Restorative Surgery, Charité / Virchow-Klinikum campus (Prof. Dr. N. Haas)
    • 4-1997
      Awarded title of Certified Specialist in Surgery
    • 10-1998 
      Post-doctoral habilitation to lecture in surgery and consultant at Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus (Prof. Dr. P. Neuhaus)
    • 1-1999
      Head of the Study Office at the Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus. Senior coordinator for organ removal and explantation services at the Clinic
    • 1-2000
      Documentation officer at Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus.
    • 3-2000
      Responsible for organ donation and explantation service
    • 11-2000
      Offical recognition of specialism in Visceral Surgery
    • 8-2001
      Section documentation officer for surgical departments at the Charité / Virchow-Klinikum Campus (Introduction of DRG system to campus)
    • 10-2001
      Responsible for department of minimally invasive surgery
    • 1-2002
      Planning and development of MDA project (medical documentation assistants) at the  Charité
    • 4-2002
      Responsible for oncological surgery and organ transplants
    • 10-2002
      Deputy head of Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus with responsibility for DRGs, budget planning and personnel
    • 2-2004
      Senior consultant at the Clinic for General, Visceral and Transplant Surgery, Charité /  Virchow-Klinikum campus
    • 11-2004
      Offical recognition of specialism in Vascular Surgery
    • 3-2006
      Appointed supernumerary professor
    • 5-2007
      Appointed head of department of Clinic for General, Vascular and Visceral Surgery, Waldkrankenhaus Evangelical Hospital, Spandau, operated by Paul-Gerhardt-Diakonie.
      Surgical focus:
      oncological surgery
      minimally invasive surgery
      transplant surgery
      vascular surgery
      thoracic surgery
  • Membership of Professional Associations / Honorary positions
    • 1991   German Transplant Society (DTG)
    • 1992   German Association for the Study of Liver Disease (GASL)
    • 1993   German Society for Surgery (DGCh)
    • 1994   Berlin Surgical Society
    • 1995   Association of Bavarian Surgeons
    • 1995   Association of North-West German Surgeons
    • 1996   Society for Gastroenterology and Hepatology in Berlin and Brandenburg
    • 1996   European Society for Organ Transplantation (ESOT)   
    • 1996   European Liver and Intestine Transplant Association (ELITA)
    • 1996   International Liver Transplant Society (ILTS)
    • 1997   International Transplantation Society (ITS)
    • 1998   German Society for Visceral Surgery
  • Selection of Publications
    (Selected publications as first and senior author of 273 entries in MEDLINE)
    • Langrehr-JM; Hoffman-RA; Banner-B; Stangl-MJ; Monyhan-H; Lee-KK; Schraut-WH. Induction of graft-versus-host disease and rejection by sensitized small bowel allografts. Transplantation. 1991; 52(3): 399-405.
    • Langrehr-JM; Hoffman-RA; Billiar-TR; Lee-KK; Schraut-WH; Simmons-RL. Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism. Surgery. 1991; 110(2): 335-42.
    • Langrehr-JM; Reilly-MJ; Banner-B; Warty-VJ; Lee-KK; Schraut-WH. Hepatic steatosis due to total parenteral nutrition: the influence of short-gut syndrome; refeeding; and small bowel transplantation. J-Surg-Res. 1991; 50(4): 335-43.
    • Langrehr-JM; Dull-KE; Ochoa-JB; Billiar-TR; Ildstad-ST; Schraut-WH; Simmons-RL; Hoffman-RA. Evidence that nitric oxide production by in vivo allosensitized cells inhibits the development of allospecific CTL. Transplantation. 1992; 53(3): 632-40.
    • Langrehr-JM; Hoffman-RA; Demetris-AJ; Lee-KK; Neuhaus-P; Wren-SM; Ildstad-ST; Schraut-WH. Evidence that indefinite survival of small bowel allografts achieved by a brief course of cyclosporine or FK506 is not due to systemic hyporesponsiveness. Transplantation. 1992; 54(3): 505-10.
    • Langrehr-JM; Muller-AR; Bergonia-HA; Jacob-TD; Lee-TK; Schraut-WH; Lancaster-JR Jr; Hoffman-RA; Simmons-RL. Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection and graft-versus-host disease after small-bowel transplantation in the rat. Surgery. 1992; 112(2): 395-401; discussion 401-2
    • Langrehr-JM; Murase-N; Markus-PM; Cai-X; Neuhaus-P; Schraut-W; Simmons-RL; Hoffman-RA. Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. J-Clin-Invest. 1992; 90(2): 679-83.
    • Langrehr-JM; Banner-B; Lee-KK; Schraut-WH. Clinical course; morphology; and treatment of chronically rejecting small bowel allografts. Transplantation. 1993; 55(2): 242-50.
    • Langrehr-JM; Hoffman-RA; Lancaster-JR Jr; Simmons-RL. Nitric oxide--a new endogenous immunomodulator. Transplantation. 1993; 55(6): 1205-12.
    • Langrehr-JM; White-DA; Hoffman-RA; Simmons-RL. Macrophages produce nitric oxide at allograft sites. Ann Surg 1993; 218 (2):159-166.
    • Langrehr-JM; Demetris-AJ; Banner-B; Müller-AR; Thalmann-U; Lee-TK; Lee-KKW; Schraut-WH. Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occurs simultaneously in indefinitely surviving recipients of small bowel allografts. Transpl Int 1994; 7:71-78.
    • Langrehr-JM; Keck-H; Lohmann-R; Blumhardt-G; Bechstein-WO; Neuhaus-P. Gegenwärtiger Stand der orthotopen Lebertransplantation: Indikation; Ergebnisse; Empfehlungen. Akt-Chir. 1994; 29: 41-6
    • Langrehr-JM; Knoop-M; Lohmann-R; Wedell-A; Kaisers-U; Berg-Th; König-V; Bechstein-WO; Hopf-U; Blumhardt-G; Neuhaus-P. Indikation und Ergebnisse der Lebertransplantation bei posthepatitischer Zirrhose. Chir Gastroenterol 1994; 10:26-31.
    • Langrehr-JM; Markus-PM; Banner-B; Lee-KKW; Schraut-WH. Induction of chronic progredient graft-versus-host disease following transplantation of sensitized small bowel allografts. Am J Surg 1994; 167:579-585.
    • Langrehr-JM; Keck-H; Knoop-M; Kratschmer-B; Neuhaus-PJ. Operative Therapie von Leberverletzungen. Akt Chir 1997; 32: 240-245.
    • Langrehr-JM; Buchen-S; von Fournier-C; Tempka-A; Keck-H; Neuhaus-P. Ergebnisse der primär-operativen Versorgung von Lebertraumata. In: Bauer H; Hartel W (Hrsg.) Kongressband 1997. Langenbeck Arch Chir 1997 (Suppl II):1247-1248.
    • Langrehr-JM; Kahl-A; Meyer-M; Neumann-U; Knoop-M; Jonas-S; Steinmüller-T; Bechstein-WO; Frei-U; Forssmann-WG; Neuhaus-P. Prophylactic use of low-dose urodilatin for prevention of renal impairment following liver transplantation: A randomized placebo-controlled study. Clin Transplant 1997; 11:593-598.
    • Langrehr-JM; Nüssler-NC; Neumann-U; Guckelberger-O; Lohmann-R; Radtke-A; Jonas-S; Klupp-J; Steinmüller-T; Lobeck-H; Meuer-S; Schlag-H; Lemmens-HP; Knoop-M; Keck-H; Bechstein-WO; Neuhaus-P. A prospective randomized trial comparing interleukin-2 receptor antibody versus ATG as part of a quadruple immunosuppressive induction therapy following orthotopic liver transplantation. Transplantation 1997; 63: 1772-1781.
    • Langrehr-JM; Glanemann-M; Guckelberger-O; Klupp-J; Neumann-U; Machens-C; Lohmann-R; Knoop-M; Lobeck-H; Schlag-H; Keck-H; Settmacher-U; Bechstein-WO; Neuhaus-PJ. A randomized; placebo-controlled trial with anti-interleukin-2 receptor antibody for immunosuppressive induction therapy after liver transplantation. Clin Transplantation 1998; 12:303-312.
    • Langrehr-JM; Neuhaus-P. Use of antilymphocyte induction therapy in liver transplantation: a european perspective. Liver Transpl Surg 1999; 5(Suppl 1):S71-S84.
    • Langrehr-JM; Machens-C; Koch-S; Zill-E; Leder-K; Nüssler-A; Hoffman-RA; Neuhaus-P. Bacterial translocation during graft-versus-host disease after small bowel transplantation is reduced following inhibition of inducible NO synthesis. Transplantation 2000; 69:2415-2421.
    • Langrehr-JM; Bahra-M; Jacob-D; Glanemann-M; Neuhaus-P. Prospective randomized comparison between a new mattress technique and Cattell (duct-to-mucosa) pancreaticojejunostomy for pancreatic resection. World J Surg. 2005; 29(9):1111-9; discussion 1120-1121.
    • Langrehr-JM; Petersen-I; Pfitzmann-R; Lopez-Hanninen-E. [Malignant epithelioid hemangioendothelioma of the liver. Results of surgical treatment strategies] Chirurg. 2005; 76(12):1161-1167.
    • Langrehr-JM; Hölzel-D; Billing-A; Krauss-T; Lück-R; Fangmann-J; Krämer-B; Lohmann-R. Verbesserung der Abbildung der Kosten der Lebertransplantation im Rahmen des G-DRG-Systems durch Kostenanalyse und Berechnung neuer Kostenseparatoren. Transplantationsmedizin; 2005; 17:88-100.
    • Langrehr-JM; Schmidt-SC; Neuhaus-P. Initial experience with the use of fibrin sealant for the fixation of the prosthetic mesh in laparoscopic transabdominal preperitoneal hernia repair. Rozhl Chir. 2005; 84(8):399-402.
    • Langrehr-JM; Pfitzmann-R; Hermann-M; Radke-C; Neuhaus-P; Pech-M; Denecke-T; Felix-R; Hanninen-EL. Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia. Acta Radiol. 2006; 47(4):340-344.
    • Langrehr-JM; Puhl-G; Bahra-M; Schmeding-M; Spinelli-A; Berg-T; Schönemann-C; Krenn-V; Neuhaus-P; Neumann-UP. Influence of donor/recipient HLA matching on outcome and recurrence of hepatitis C after liver transplantation. Liver Transplantation 2006; 12:644-651.
    • Langrehr-JM; Klupp-J; Glanemann-M; Junge-G; Pfitzmann-R; Bahra-M; Radke-C; Neumann-U; Neuhaus-R; Neuhaus-P. Long-term results of microphenolate mofetil as part of immunosuppressive induction therapy after liver transplantation. Clinical Transplantation 2006; 20:272-283
    • Langrehr-JM, Bahra-M, Kristiansen-G, Bausch-B, Neumann-LM, Neumann-HPH, Plöckinger-U, Lopez-Hänninen-E. Neuroendocrin tumor of the pancreas and bilateral adrenal pheochromocytomas. A rare manifestation of von-Hippel-Lindau disease in childhood; J Pediatr Surg 2007; 42:1291-1294.
    • Langrehr-JM, Hammer-MH, Gube-K, Lehmann-M, Polenz-D, Pascher-A, Volk-HD, Reinke-P. Short term anti-CD4 plus anti-TNF-alpha receptor treatment in allogeneic small bowel transplantation results in long-term allograft survival. Transplantation 2001; 84:639-645.
    • Bahra-M; Langrehr-JM. Neuer Aspekte der chirurgischen Therapie des Pankreaskarzinoms. Journal Onkologie 2003; 5:24-27.
    • Schmidt-SC; Adler-A; Keck-H; Veltzke-Schlieker-W; Hintze-RE; Langrehr-JM. Traumatic disruption of the proximal hepatic duct: endoscopic treatment after failure of surgical repair. Endoscopy. 2004; 36(12):1128-1129.
    • Guckelberger-O; Stange-B; Glanemann-M; Lopez-Hanninen-E; Heidenhain-C; Jonas-S; Klupp-J; Neuhaus-P; Langrehr-JM. Hepatic resection in liver transplant recipients: single center experience and review of the literature. Am J Transplant. 2005; 5(10):2403-2409.
    • Jacob-DA; Neumann-UP; Bahra-M; Klupp-J; Puhl-G; Neuhaus-R; Langrehr-J. Long-term follow-up after recurrence of primary biliary cirrhosis after liver transplantation in 100 patients. Clinical Transplantation 2006; 20(2):211-220.
    • Guckelberger-O; Mutzke-F; Glanemann-M; Neumann-UP; Jonas-S; Neuhaus-R; Neuhaus-P; Langrehr-JM. Validation of cardiovascular risk scores in a liver transplant population. Liver Transpl. 2006; 12(3):394-401.
    • Lohmann-R; Krämer-B; Schaefer-O; Becker-T; Lopez-Hänninen-E; Langrehr-JM. Das DRG-Projekt der Deutschen Transplantationsgesellschaft – 2. Einführung neuer DRGs in das System 2005: Evaluierungsaufenthalt vor Transplantation bei verschiedenen Organen. Transplantationsmedizin 2006; 18:36-43.
    • Lopez Hanninen-E; Pech-M; Ricke-J; Denecke-T; Amthauer-H; Lehmkuhl-L; Bohmig-M; Rottgen-R; Pinkernelle-J; Felix-R; Langrehr-J. Magnetic resonance imaging in the assessment of cystic pancreatic lesions: differentiation of benign and malignant lesion status. Acta Radiol. 2006; 47(2):121-129.
    • Schmidt-SC; Langrehr-JM. Autologous fibrin sealant (Vivostat) for mesh fixation in laparoscopic transabdominal preperitoneal hernia repair. Endoscopy 2006; 38:841-844.
    • Schmitz-V; Neumann-UP; Neuhaus-P; Langrehr-JM. Surgical complications and long-term outcome of different biliary  reconstructions in liver transplantation for primary sclerosing cholangitis-choledochoduodenostomy versus choledochojejunostomy. Am J Transplant. 2006; 6(2):379-385.
    • Jacob-DA, Bahra-M, Langrehr-JM. Jejunal loop drainage versus direct pancreatic duct drainage after pancreatic head resection. Surg Today 2006; 36:898-907.