Prof. Dr. med. Ulrich Nöth, MHBA
Senior Consultant of the Department of Orthopaedics and Trauma Surgery at Evangelisches Waldkrankenhaus Spandau
Main operative areas
• Primary hip and knee joint endoprosthetics (especially minimally invasive)
• Revision endoprosthetics of the hip and knee joint of all degrees of severity
• Tumour endoprosthetics/tumour surgery
• Hip joint surgery, impingement surgery (open and arthroscopic)
• Knee joint surgery
• Shoulder surgery
• Rheumatic orthopaedics
• Articular cartilage surgery and cell-based reconstructive procedures of all joints
Main research areas
• Hip and knee joint endoprosthetics
• Stem cell technology
• Revision endoprosthetics
• Articular cartilage reconstruction
• Development of new operative concepts for the treatment of arthrosis
• Tissue engineering of the musculoskeletal system
• Translational regenerative medicine
• Clinical trials phase I and II (in particular cell-based procedures in accordance
with the Tissue Act)
Career
University study 1988 - 1991 Study of Medicine, University of Regensburg
1991 - 1996 Study of Medicine, University of Würzburg
Licence to practise 01.12.1997
medicine
Doctorate 10.03.1998 (magna cum laude)
Subject: “Glutathione and glucose-6-phosphate dehydrogenase activity in 6-hydroxydopamine and TaClo-(1-trichloro-methyl-1,2,3,4-tetrahydro-beta-carboline) animal models of Parkinson’s disease and in vitamin E-treated rats” (Prof. Riederer, Clinical Neurochemistry, University of Würzburg)
Postdoctoral thesis 28.11.2007 “Tissue engineering of the
(cumulative) musculoskeletal system with human
mesenchymal stem cells”
MHBA 07.10.2011 Master of Health Business Administration MHBA (Hospital Management), Subject of the Master’s dissertation: Quality assurance in hip and knee joint prosthetics (University of Erlangen-Nuremberg, Prof. Oliver Schöffski)
Adjunct professor 13.02.2012 Appointed Adjunct Professor of the University of Würzburg
Professional training/career
Oct. 1995 – Dec. 1995 Elective Student, Department of Orthopaedic Surgery, University College London Medical School, London, UK (Prof. George Bentley)
Dec. 1995 – Feb. 1996 Elective Student, Department of Internal Medicine, Regionalspital Samedan/St. Moritz
(Dr. med. H. Herold)
Jun. 1996 – Nov. 1997 House Officer, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
Dec. 1997 – Oct. 1998 Senior House Officer, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
Nov. 1998 – Nov. 2000 DFG Postdoctoral Research Fellow, Department of Orthopaedic Surgery, Division of Orthopaedic Research, Tissue Engineering Program, Thomas Jefferson University, Rothman Institute, Philadelphia, PA, U.S.A. (Rocky S. Tuan, PhD/ Richard H. Rothman, MD, PhD)
Dec. 2000 – Sept. 2002 Senior House Officer, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
Jan. 2001 Head of the Section Tissue Engineering/
Regenerative Medicine, Orthopaedic Centre for Musculoskeletal Research (OZMF), Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
Oct. 2002 – Sept. 2003 Senior House Officer (Surgical Year),
Surgical University Clinic, University of Würzburg (Prof. Dr. med. Arnulf Thiede)
Oct. 2003 – May 2005 Senior House Officer, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
June 2005 Recognised as Specialist in Orthopaedics
July 2006 Consultant, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
July 2007 Consultant in Charge, Main Specialist Area Endoprosthetics, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. Jochen Eulert)
July 2009 Optional Further Training in Special Orthopaedic Surgery
July 2009 Managing Consultant, Orthopaedic Clinic, König-Ludwig-Haus, Chair of Orthopaedics of the University of Würzburg (Prof. Dr. med. M. Rudert)
September 2009 Course of study “Master of Health Business Administration” (MHBA), University of Erlangen
January 2010 Director of the Specialist Area Rheumatic Orthopaedics
April 2010 Director of the newly founded research laboratory Translational Orthopaedics
October 2011 Master of Health Business Administration (MHBA) (Hospital Management)
February 2012 Appointed Adjunct Professor of the Faculty of Medicine, Würzburg
April 2012 Co-founder of CoBaLT Implantate GmbH
with headquarters in Würzburg
March 2013 Specialist in Orthopaedics and Trauma Surgery
April 2013 Appointed Centre Co-ordinator of the Würzburg Endoprosthetic Centre
January 2014 Senior Consultant of the Department of Orthopaedics and Trauma Surgery, Evangelisches Waldkrankenhaus Berlin
Executive and Management Experience
• Managing Consultant
• Consultant in Charge of the Specialist Area Endoprosthetics
• Centre Co-ordinator of the Main-Franconian Endoprosthetic Centre
• Director of the Specialist Area Rheumatic Orthopaedics
• Head of the Section Tissue Engineering/Regenerative Medicine and Translational Orthopaedics (Orthopaedic Centre for Musculoskeletal Research (OZMF), Würzburg)
Additional Qualifications, Further Training
• Specialist Training in Radiation Protection
• Ultrasound of the infant hip (DEGUM)
• Ultrasound of the Supporting and Movement Organs (DEGUM)
• Basic Course in Animal Welfare and Laboratory Animal Science
• Evidence Based Medicine (EBM), Winterthur Institute of Health Economics
• Investigator (ICH-GCP)
• Specialist in Orthopaedics
• Specialist in Orthopaedics and Trauma Surgery
• Special Orthopaedic Surgery
• Rheumatic Orthopaedics (admitted for the examination)
Current Clinical Research Projects (Principal Investigator)
• Anterior vs. lateral access in hip joint prosthetics 5 years (retrospective)
• Anterior vs. lateral access in hip joint prosthetics (prospective)
• Outcome of the Nanos short stem prosthesis (prospective)
• Results of iliopsoas release with previous malposition of the acetabulum
• Surgical hip joint dislocation vs. direct anterior access vs. hip joint arthroscopy
• Outcome of collagen hydrogels for the reconstruction of cartilage defects on the hip joint (CaReS – one step)
• Activity following primary knee endoprosthesis
• Outcome of axially coupled knee prostheses
• Outcome of the RHK knee revision endoprosthesis (Biomet)
• Impaction bone grafting in knee revision endoprosthetics
• Tuberosity osteotomy due to reduced flexion following total knee joint replacement
• Cartilage transplant in the knee joint (Multicentre Study CaReS – one step)
• Cerasorb bone replacement with benign bone tumours and tumour-like lesions
• Intra-articular injection of fat stem cells for the treatment of knee joint arthrosis (Clinical Trial Phase I in accordance with the Tissue Act)
Grants/fellowships
German Research Foundation, Postdoctoral Grant USA (2 years), Bonn. Reference number NO 371/1-1, “Integrin-transferred adhesion of osteoblasts onto orthopaedic implant surfaces”, (Rocky S. Tuan, PhD, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, U.S.A.)
DGOOC (German Association of Orthopaedics and Orthopaedic Surgery) ASG (Austria Swiss German) Fellowship in 2008
Working Group on Endoprosthetics, Working Group on Endoprosthetics Travel Grant in 2008 to the Conference “Current Concepts in Total Hip and Knee Arthroplasty”, Orlando (USA)
Awards and distinctions (selected)
2001
NIRA (New Investigator Recognition Award) of the ORS (Orthopaedic Research Society) U.S.A., Orlando, 2001. Nöth U, Osyczka A, Tuli R, Danielson KG, Tuan RS. Multipotential mesenchymal cell cultures derived from human trabecular bone. Trans Orthop Res Soc 47:310, 2001.
2003
Forum Award of the VDPC (Association of German Plastic Surgeons), Freiburg, 2003. Kall S, Nöth U, Reimers K, Choi C, Mühlberger T, Mala M, Jahn S, Allmeling C, Vogt PM. In vitro production of long tendon constructs using a bioreactor for cyclic expansion. Plast Chir 3 (S1):8-9, 2003
2006
Themistocles-Gluck Award 2006 of the DGOOC (German Association of Orthopaedics and Orthopaedic Surgery). Baumann B, Seufert J, Jakob F, Nöth U, Rolf O, Eulert J, Rader CP. Activation of NF-kappaB signalling and TNFalpha-expression in THP-1 macrophages by TiAlV- and polyethylene-wear particles. J Orthop Res 23:1241-8, 2006.
2007
Von-Recklinghausen Award 2007 of the DGE (German Society of Endocrinology). Schilling T, Nöth U, Klein-Hitpass L, Jakob F, Schütze N. Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells. Mol Cell Endocrinol 271:1-17, 2007.
2009
Hans-Jürgen Bretschneider Award of the DGU (German Society of Trauma Surgery) 2009. Steinert A, Kunz M, Proffen B, Weissenberger M, Nöth U, Evans C, Rudert M. 13th Annual Surgical Meeting of the Section Surgical Research of the German Society of Surgery in Munich awarded for the conference paper: Gene-induced chondrogenesis for cartilage repair – Screening of different transgenes and potential for hypertrophy reduction.
Poster Prize in the Conference Soft Tissue experimental 2009. 23.10.2009 German Conference for Orthopaedics and Trauma Surgery (DKOU) in Berlin awarded for the poster and short paper: Steinert A, Stehle J, Kunz M, Jakob F, Nöth U, Gohlke F: "Subacromial bursa: stem cell deposit in the shoulder with relevance for the healing of rotator cuff defects – a molecular analysis".
AFOR Science Award of the Swiss foundation AFOR (Association for Orthopaedic Research) for the paper: Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Steinert AF, Palmer GD, Pilapil C, Nöth U, Evans CH, Ghivizzani SC. Tissue Eng Part A. 2009 May;15(5):1127-39
2010
Research Group Award of the German Academy of Osteological and Rheumatological Sciences (DAdorW) for the Orthopaedic Centre for Musculoskeletal Research (OZMF) at the Chair of Orthopaedics under the Direction of Prof. Dr. Franz Jakob
AGA Poster Prize of the German-speaking Association of Arthroscopy (AGA) on the occasion of the 27th AGA Conference in Vienna, for the best poster from research with the title: Injection of stem cells for the treatment of the fat-infiltrated rotator cuff, to: Nöth U, Rackwitz L, Steinert A, Gohlke F, Rolf O, Weber-Haddad M.
2011
Wilhelm-Roux Award of the Section Basic Research of the DGOU (German Society of Orthopaedics and Trauma Surgery) for the Best Paper from Experimental Research at the Annual Conference of the DGOU for the paper “Collagen I-nanofiber scaffolds – influence of anisotropy on the tenogenic differentiation of mesenchymal stem cells”, to: Broermann R, Hallinger R, Pullig O, Rudert M, Nöth U, Rackwitz L.
Activity in scientific societies, associations, honorary posts
In an executive or advisory function
• Member of the Full Management Board of the DGOOC (German Association of Orthopaedics and Orthopaedic Surgery), since 2012
• Chairman of the Forum of Salaried Orthopaedists (NSO) of the (DGOOC) (German Association of Orthopaedics and Orthopaedic Surgery), since 2012
• Board Member of the Section Basic Sciences of the DGOOC (German Association of Orthopaedics and Orthopaedic Surgery), since 2006
• Board Member of TERMIS-EU Registered Society. (Tissue Engineering and Regenerative Medicine International Society – European Chapter), since 2005
• Chairman and Founder of the Würzburg Initiative Tissue Engineering Registered Society (WITE e.V.), since 2003
• From 2006 to 2011 Member of the External Scientific Advisory Board of the Paul Ehrlich Institute (PEI, Federal Agency for Sera and Vaccines)
Full member (international)
• Orthopaedic Research Society (ORS), since 1999
• International Cartilage Repair Society (ICRS), since 2000
• TERMIS (Tissue Engineering and Regenerative Medicine International Society), since 2003
• Société International de Chirurgie Orthopédique et de Traumatologie (SICOT), since 2009
Full member (national)
• German Association of Orthopaedics and Orthopaedic Surgery (DGU), since 1999
• Working group “Tissue regeneration and tissue replacement” of the (DGOOC), since 2004
• Section basic research of the DGOOC, since 2006
• Working group “Network of Regenerative Orthopaedics” of the German Association of Orthopaedics and Orthopaedic Surgery (DGOOC), since 2006
• Association for the Promotion of Orthopaedic Sciences, Würzburg, since 2006
• Project Group of Endoprosthetics/ComGen (AEComGen), since 2007
• Working Group (EBM) Evidence Based Medicine of the DGOU (German Society of Orthopaedics and Trauma Surgery), since 2008
• Project Group of Regional Co-operative Rheumatic Centres in the German Society of Rheumatology, since 2009
Editorial Board Memberships
• Stem Cell Research & Therapy (IF = 3.21)
(Editors-in-Chief: Rocky S Tuan, University of Pittsburgh School of Medicine,
Timothy O'Brien, National University of Ireland, Galway)
• ISRN Stem Cells
(Hindawi Publishing Corporation)
Advisory activities
Research collaborations
• German Research Foundation (DFG), Germany
• Austrian Science Fund (FWF), Austria
• National Medical Research Council, Singapore
Journals (selected)
• Biomaterials
• Biotechnology and Bioengineering
• BMC Musculoskeletal Disorders
• Cytotherapy
• European Biophysics Journal
• European Journal of Cell Biology
• Histochemistry and Cell Biology
• Journal of Biomedical Material Research/Part A
• Journal of Biomaterials Application
• Journal of Shoulder and Elbow Surgery
• Journal of Tissue Engineering and Regenerative Medicine
• Operative Orthopaedics and Traumatology
• Stem Cell Research & Therapy
inter alia.
Patents
Weber/Haddad/Nöth: Cruciate ligament reconstruction with collagen I fibers
(submitted to the Federal Patent Office in December 2009, DE 10 2009 059 901.0 and PCT/EP2010/070312)
